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KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>

2023-12-08

Abstract excerpt

Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG encoded bifunctional catalase-peroxidase. We hypothesised that perturbed KatG activity would generate collateral vulnerabilities in INH-resistant katG mutants, providing new pathways to combat isoniazid resistance. Here, we used...

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Identifiers and source

Literature Corpus work
e18da708-ce60-5056-9d46-240dec646246
DOI
10.1101/2023.12.07.570702
Open publication

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