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Article

Mutant ATRX: uncovering a new therapeutic target for glioma.

Expert opinion on therapeutic targets - 1 Jul 2018

Haase Santiago, Garcia-Fabiani María Belén, Carney Stephen, Altshuler David, Núñez Felipe J, Méndez Flor M, Núñez Fernando, Lowenstein Pedro R, Castro Maria G

Abstract excerpt

INTRODUCTION: ATRX is a chromatin remodeling protein whose main function is the deposition of the histone variant H3.3. ATRX mutations are widely distributed in glioma, and correlate with alternative lengthening of telomeres (ALT) development, but they also affect other cellular functions related to epigenetic regulation. Areas covered: We discuss the main molecular characteristics of ATRX, from its various...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29889582
DOI: 10.1080/14728222.2018.1487953
PMCID: PMC6044414

Genes

ATRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Functional analysis of telomere maintenance mechanisms is more informative than immunohistochemistry for ATRX mutation interpretation in Gliomas.Semantic proximity Read ↗

Functional Assessment of ATRX Alterations Improves Glioma DiagnosisSemantic proximity Read ↗

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific mannerSemantic proximity Read ↗

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