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The Chromatin Remodeler ATRX: Role and Mechanism in Biology and Cancer

10 Apr 2023

Abstract excerpt

The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of ATRX, including its molecular structures and normal and malignant biological roles, are...

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PMID: 37190157
DOI: 10.3390/cancers15082228

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