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Article

Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection.

Nature communications - 4 Sept 2018

Chow Tracy T, Shi Xiaoyu, Wei Jen-Hsuan, Guan Juan, Stadler Guido, Huang Bo, Blackburn Elizabeth H

Abstract excerpt

Enhanced telomere maintenance is evident in malignant cancers. While telomeres are thought to be inherently heterochromatic, detailed mechanisms of how epigenetic modifications impact telomere protection and structures are largely unknown in human cancers. Here we develop a molecular tethering approach to experimentally enrich heterochromatin protein HP1α specifically at telomeres. This results in increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30181605
DOI: 10.1038/s41467-018-05840-y
PMCID: PMC6123478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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