Article

Histone Variant H3.3 Mediates DNA Repair and cGAS-STING Pathway Activation in Telomere Dysfunction

2024-08-08

Abstract excerpt

<h4>ABSTRACT</h4> The telomere damage response is a critical mechanism regulating human aging and disease progression. Deprotected telomeres activate the cytosolic DNA-sensing cGAS-STING pathway; however, the underlying mechanism remains unclear. Here, we discover that histone H3.3 is required for cGAS-STING pathway activation in cells with deprotected telomeres. Expression of the TRF2 dominant-negative mutant, T...

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Literature Corpus work: e131d33f-350a-5e92-b6c3-f12db092d2cc
DOI: 10.1101/2024.08.07.606966

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