Article

Beyond BRCA: Discovery of novel causes and consequences of homologous recombination deficiencies

2022-10-05

Abstract excerpt

<h4>SUMMARY</h4> Since the discovery of BRCA1 and BRCA2 mutations as cancer risk factors, we have gained substantial insight into their role in maintaining genomic stability through homologous recombination (HR) DNA repair. However, upon pan-cancer analysis of tumors from The Cancer Genome Atlas (TCGA), we found that mutations in BRCA1/2 and other classical HR genes only identified 10-20% of tumors that displa...

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Literature Corpus work: 212a8c84-93e1-58e8-b5b7-842e40887ce5
DOI: 10.1101/2022.10.01.510467

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