Article
Pdap1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification
2020-01-31
Abstract excerpt
The establishment of protective humoral immunity is dependent on the ability of mature B cells to undergo antibody gene diversification while adjusting to the physiological stressors induced by activation with the antigen. Mature B cells diversify their antibody genes by class switch recombination (CSR) and somatic hypermutation (SHM), which are both dependent on efficient induction of activation-induced cytidine...
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Identifiers and source
- Literature Corpus work
- fd4b0451-6c20-5ac2-9b99-e1d75b718bfc
- DOI
- 10.1101/2020.01.30.917062