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Article

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

25 Oct 2021

Abstract excerpt

In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular, and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast...

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PMID: 34723157
DOI: 10.1016/j.isci.2021.103325

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