Article

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination

2018-04-13

Abstract excerpt

Adaptive immune responses require the generation of a diverse repertoire of immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of antigens. V(D)J recombination creates the primary Ig repertoire, which subsequently is modified by somatic hypermutation (SHM) and class switch recombination (CSR). SHM promotes Ig affinity maturation whereas CSR alters the effector function of the Ig. B...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2349e1d9-29f5-58f9-9ad8-119d423d3fda
DOI: 10.12688/f1000research.13247.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombinationDOI 10.12688/f1000research.13247.1Read

DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic HypermutationSemantic proximity Read

Immunoglobulin class-switch recombination deficienciesSemantic proximity Read

Mismatch-mediated error prone repair at the immunoglobulin genes.Semantic proximity Read

The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical RamificationsSemantic proximity Read

Immunoglobulin somatic hypermutation.Semantic proximity Read

AID in Antibody Diversification: There and Back Again.Semantic proximity Read

Immunoglobulin Gene DiversificationSemantic proximity Read

The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models.Semantic proximity Read

AID-initiated purposeful mutations in immunoglobulin genes.Semantic proximity Read

Controlling somatic hypermutation in immunoglobulin variable and switch regions.Semantic proximity Read

Epigenomic Modifications Mediating Antibody MaturationSemantic proximity Read

Immunological disorders and DNA repair.Semantic proximity Read