Article

Maturation Trajectories and Transcriptional Landscape of Plasmablasts and Autoreactive B Cells in COVID-19

2021-07-12

Abstract excerpt

In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular and transcriptomic imprints of pathological responses linked to autoreactive B cells at single-cell resolution. We show that excessive plasmablast expansions...

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Literature Corpus work: c5bcce9a-a9f7-528d-86fd-804c973e1393
DOI: 10.2139/ssrn.3885240

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