Article

Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis

2024-08-02

Abstract excerpt

The nuclear genome is spatially organized into a three-dimensional (3D) architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina at the radial periphery and nuclear speckles within the nucleoplasm 1–5 . However, how spatial genome architecture regulates human brain development has been overlooked owing to technical limitations. Here, we generate h...

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Literature Corpus work: d2e93df3-93b0-5611-8ea3-fdf3bb8e25e8
DOI: 10.1101/2024.08.01.606248

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