Article

GSK-3484862 targets DNMT1 for degradation in cells

2022-11-04

Abstract excerpt

<h4>ABSTRACT</h4> Maintenance of genomic methylation patterns at DNA replication forks by DNMT1 is the key to faithful mitotic inheritance. DNMT1 is often overexpressed in cancer cells and the DNA hypomethylating agents azacytidine and decitabine are currently used in the treatment of hematologic malignancies. However, the toxicity of these cytidine analogs and their ineffectiveness in treating solid tumors have...

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Literature Corpus work: 71488f45-9a36-5321-9e3d-2b753ec28266
DOI: 10.1101/2022.11.03.514954

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