Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases.

doi:10.1016/j.sbi.2022.102433

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Article

Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases.

Current opinion in structural biology - 1 Aug 2022

Cheng Xiaodong, Blumenthal Robert M

Abstract excerpt

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and regulatory factors involved in processes that include histone modifications. Methylation in a sequence longer than CpG can influence the binding of sequence-specific transcription factors, thus affecting gene expression. 5-Methylcytosine deamination results...

Topics

Animals
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases
DNA Methylation
DNA Methyltransferase 3A
Mammals
Mutation
DNA Methyltransferase 3B

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Identifiers

PMID: 35914495
DOI: 10.1016/j.sbi.2022.102433
PMCID: PMC9620438

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