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Targeting DNA Methylation

15 Jun 2009

Abstract excerpt

Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. These old drugs, developed as cytotoxic agents and nearly abandoned decades ago were resurrected by the renewed interest in DNA methylation. They have now provided proof of principle for epigenetic therapy, the final chapter in the long...

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PMID: 19509174
DOI: 10.1158/1078-0432.ccr-08-2783

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