Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function

2 Sept 2014

Abstract excerpt

It is poorly understood why there is greater cardiovascular disease risk associated with the apolipoprotein E4 (apoE) allele vs. apoE3, and also greater risk with the LRP8/apolipoprotein E receptor 2 (ApoER2) variant ApoER2-R952Q. Little is known about the function of the apoE-ApoER2 tandem outside of the central nervous system. We now report that in endothelial cells apoE3 binding to ApoER2 stimulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis and Cardiovascular Diseases
Share to Cholesterol and Lipid Metabolism
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25197062
DOI: 10.1073/pnas.1402106111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants of ApoE and ApoER2 differentially modulate endothelial functionPMID 25197062Read ↗

Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseasesSemantic proximity Read ↗

ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesisSemantic proximity Read ↗

The Impact of the Apolipoprotein E Genotype on Cardiovascular Disease and Cognitive Disorders.Semantic proximity Read ↗

ApoE4 Promotes Thrombosis via Endothelial Cell ApoER2 and PP2A ActivationSemantic proximity Read ↗

Apolipoprotein E: far more than a lipid transport protein.Semantic proximity Read ↗

Apolipoprotein E receptors in the nervous systemSemantic proximity Read ↗

The role of APOE in cerebrovascular dysfunction.Semantic proximity Read ↗

Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathologySemantic proximity Read ↗

The Role of Impaired Receptor Trafficking in Mediating the Pathological Effects of ApoE4 in Alzheimer DiseaseSemantic proximity Read ↗

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of InflammationSemantic proximity Read ↗

Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injurySemantic proximity Read ↗

Impact of Apolipoprotein E4 on Blood-Brain Barrier Integrity in Target Replacement Murine Models: A Systematic Review and Meta-AnalysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.