Article

SVEP1, a novel human coronary artery disease locus, promotes atherosclerosis

2020-06-16

Abstract excerpt

<h4>Summary</h4> A low-frequency variant of SVEP1, an extracellular matrix protein, is associated with risk of coronary disease in humans independent of plasma lipids. Despite a robust statistical association, however, it was unclear if and how SVEP1 might contribute to atherosclerosis. Here, using Mendelian randomization and complementary mouse models, we provide evidence that SVEP1 promotes atherosclerosis in h...

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Literature Corpus work: 3d7bbe86-c8e7-5d6b-b6b2-437902b85eb6
DOI: 10.1101/2020.06.15.151027

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