Article

Basement membrane hydrogels dampen CAR-T cell activation: nanofibrillar cellulose gels as alternative to preserve T cell function in 3D cell cultures

2024-11-03

Abstract excerpt

<h4>Background</h4> Hydrogel-based 3D culture systems are emerging as a valuable tool for preclinical screening of cell-based immunotherapies against solid and hematological malignancies, such as chimeric antigen receptor T (CAR-T) cells. Hydrogels can influence T cell function in a non-desired manner due to their mechanical properties and chemical composition, potentially skewing results in preclinical testing o...

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Literature Corpus work: fcdb4ae0-a014-5e21-9ecc-fb3e52e731d2
DOI: 10.1101/2024.10.29.620948

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