Article

Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices

2025-08-27

Abstract excerpt

Therapeutic T-cell engineering ex vivo from human hematopoietic stem cells (HSCs) focuses on recapitulating notch1-signaling and α4β1-integrin-mediated adhesion within the thymic niche with supportive stromal cell feeder-layers or surface-immobilized recombinant protein-based engineered thymic niches (ETNs). The relevant Notch1-DLL-4 and α4β1-integrin-VCAM-1 interactions are known to respond to mechanical forces...

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Literature Corpus work: 71cd89c7-1e1d-54bb-8211-0b56eaeb3967
DOI: 10.1101/2025.08.27.671384

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