Article

Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructs

2025-06-24

Abstract excerpt

Despite various therapeutic advancements in cancer, heterogeneity in the tumor microenvironment is a major hindrance to the overall efficacy of treatment. In this study, we focus on the most abundantly found cellular stromal components – fibroblasts – which can be tumor-promoting or tumor-suppressing based on the extent of disease progression and numerous additional factors. In the studies described herein, we eva...

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Literature Corpus work: 4be9bc94-5da8-577a-920d-ebf15b269dee
DOI: 10.1101/2025.06.18.660473

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