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Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

17 Mar 2024

Abstract excerpt

Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer-associated fibroblasts (CAFs) beyond previously established single-gene markers. Functional analyses of individual CAF subsets within the tumor microenvironment are critical to develop more accurate CAF-targeting therapeutic strategies. However, there is a lack of robust preclinical models that reflect this heterogeneity in...

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PMID: 38493497
DOI: 10.1002/advs.202307129

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