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Matrix composition modulates cancer cell phenotypes and secretions in a blood-brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid.

Biomaterials - 1 Oct 2026

Dabaja Ali A, Hoque Apu Ehsanul, Zhao Victor, Manimaran Sivani, Slayton Mark D, Li Huiling, Serhan Habib, Bao Liwei, Morikawa Aki, Lowenstein Pedro R, Castro Maria G, Merajver Sofia D, Oliver Christopher Ryan

Abstract excerpt

Recent advances in organ-on-a-chip (OOC) blood-brain barrier (BBB) models for oncology research have revealed key insights into the metastatic cascade. However, in most 3D BBB systems, type I collagen is commonly selected as the brain-side extracellular matrix (ECM) due to its ease of use and affordability. This selection overlooks the native ECM composition of the brain, which is primarily composed of...

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Blood-Brain Barrier
Cell Line, Tumor
Collagen
Collagen Type I
Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hyaluronic Acid

Lab-On-A-Chip Devices

Tumor Microenvironment

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Identifiers

PMID: 41999709
DOI: 10.1016/j.biomaterials.2026.124224

Genes

CXCL5
DKK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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