Back to search

Article

Seminiferous tubule–inspired coaxial bioprinting–derived extracellular vesicles restore Leydig cell steroidogenesis by restraining Wnt4/β-catenin signaling

2026-02-17

Abstract excerpt

<title>Abstract</title> <p>Chemotherapy-associated gonadotoxicity compromises Leydig cell steroidogenesis and leads to testosterone deficiency, yet repair is hindered by the testicular barrier–immune niche and by limited manufacturability of biologics. Inspired by the tubular architecture of seminiferous tubules, we develop a coaxial bioprinting–enabled encapsulation culture that generates continuous core–shell h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
95d105b1-4d30-5322-a92d-16ce47130ae0
DOI
10.21203/rs.3.rs-8836594/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Seminiferous tubule–inspired coaxial bioprinting–derived extracellular vesicles restore Leydig cell steroidogenesis by restraining Wnt4/β-catenin signalingDOI 10.21203/rs.3.rs-8836594/v1
The use of testicular organoids in advancing future treatments for male factor infertilitySemantic proximity
Dynamic Mechanical Loading Reprograms Meniscus Cell-Derived Extracellular Vesicles to Enhance Their Regenerative PotencySemantic proximity
Microfluidic bioprinting for the in vitro generation of novel biomimetic human testicular tissuesSemantic proximity
A Testis-Derived Hydrogel as an Efficient Feeder-Free Culture Platform to Promote Mouse Spermatogonial Stem Cell Proliferation and DifferentiationSemantic proximity
Microporous Immune-Isolating Capsule with Improved Diffusion for Restored Dynamic Bidirectional Hormone Signaling in a Murine Model of Premature Ovarian InsufficiencySemantic proximity
Using clinically derived human tissue to 3-dimensionally bioprint personalized testicular tubules for in vitro culturing: first reportSemantic proximity
Exploring the Convergence of Nanomedicine Application in Organoid Research Through a Scientometric Overview of Publications from 2015-2025Semantic proximity
A versatile microfluidic extrusion-based hydrogel platform for self-organization and long-term maintenance of engineered 3D lymphatic endotheliumSemantic proximity
Assessing the landscape of clinical trials involving bioprinting: a scoping review protocolSemantic proximity
PF-127 Hydrogel-Delivered hUCMSC-Exosomes Attenuate Endometrial Injury by Inhibiting Epithelial–Mesenchymal TransitionSemantic proximity
Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing PotentialSemantic proximity
Plant-derived exosome-like nanovesicles improve testicular injury by alleviating cell cycle arrest in Sertoli cellsSemantic proximity
Select a neighboring publication to make it the new centre.