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A Thy-1–negative immunofibroblast population emerges as a key determinant of fibrotic outcomes to biomaterials

14 Jun 2024

Abstract excerpt

Fibrosis-associated fibroblasts have been identified across various fibrotic disorders, but not in the context of biomaterials, fibrotic encapsulation, and the foreign body response. In other fibrotic disorders, a fibroblast subpopulation defined by Thy-1 loss is strongly correlated with fibrosis yet we do not know what promotes Thy-1 loss. We have previously shown that Thy-1 is an integrin regulator enabling...

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PMID: 38875340
DOI: 10.1126/sciadv.adf2675

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