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Article

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease.

American journal of human genetics - 2 Jun 2016

Dumanski Jan P, Lambert Jean-Charles, Rasi Chiara, Giedraitis Vilmantas, Davies Hanna, Grenier-Boley Benjamin, Lindgren Cecilia M, Campion Dominique, Dufouil Carole, Pasquier Florence, Amouyel Philippe, Lannfelt Lars, Ingelsson Martin, Kilander Lena, Lind Lars, Forsberg Lars A

Abstract excerpt

Men have a shorter life expectancy compared with women but the underlying factor(s) are not clear. Late-onset, sporadic Alzheimer disease (AD) is a common and lethal neurodegenerative disorder and many germline inherited variants have been found to influence the risk of developing AD. Our previous results show that a fundamentally different genetic variant, i.e., lifetime-acquired loss of chromosome Y (LOY) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27231129
DOI: 10.1016/j.ajhg.2016.05.014
PMCID: PMC4908225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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