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Article

Common DNA methylation alterations of Alzheimer's disease and aging in peripheral whole blood.

Oncotarget - 12 Apr 2016

Li Hongdong, Guo Zheng, Guo You, Li Mengyao, Yan Haidan, Cheng Jun, Wang Chenguang, Hong Guini

Abstract excerpt

Alzheimer's disease (AD) is a common aging-related neurodegenerative illness. Recently, many studies have tried to identify AD- or aging-related DNA methylation (DNAm) biomarkers from peripheral whole blood (PWB). However, the origin of PWB biomarkers is still controversial. In this study, by analyzing 2565 DNAm profiles for PWB and brain tissue, we showed that aging-related DNAm CpGs (Age-CpGs) and AD-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26943045
DOI: 10.18632/oncotarget.7862
PMCID: PMC4991367

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