Article

DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer’s disease

2024-08-20

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a common and increasing societal problem due to the extending human lifespan. In males, loss of chromosome Y (LOY) in leukocytes is strongly associated with AD. We studied here DNA methylation and RNA expression in sorted monocytes and granulocytes with and without LOY from male AD patients. Through multi-omic analysis, we identified new candidate genes and confirmed t...

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Literature Corpus work: ffca2741-2d30-5dce-b2de-b5c8daf9f9a9
DOI: 10.1101/2024.08.19.24312211

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