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Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment.

Genes - 8 Dec 2021

Rabaneda-Bueno Rubén, Mena-Montes Beatriz, Torres-Castro Sara, Torres-Carrillo Norma, Torres-Carrillo Nora Magdalena

Abstract excerpt

Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term functional and cognitive impairment and greatly reduces life expectancy. Early genetic studies focused on tracking variations in genome-wide DNA sequences discovered several polymorphisms and novel susceptibility genes associated with AD. However, despite the numerous risk factors already identified, there is still no fully...

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Identifiers

PMID: 34946908
DOI: 10.3390/genes12121959
PMCID: PMC8700838

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