Article

Interferon gamma signaling drives cardiac metabolic rewiring

2025-09-07

Abstract excerpt

<h4>Background</h4> IFN-gamma (IFN-γ) signaling influences myocardial inflammation and fibrosis across a wide range of conditions, including ischemic and non-ischemic heart failure (HF). However, the direct effects of IFN-γ on cardiomyocytes remain poorly understood. Here, we developed a novel in vivo model to investigate how IFN-γ impacts myocardial metabolism and function. <h4>Methods</h4> Male C57BL/6J mice w...

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Literature Corpus work: 2988a244-2e54-5395-92a7-dc8dfc38550d
DOI: 10.1101/2025.08.31.673391

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