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Article

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria.

Aging cell - 1 Aug 2010

Dai Dao-Fu, Chen Tony, Wanagat Jonathan, Laflamme Michael, Marcinek David J, Emond Mary J, Ngo Calvin P, Prolla Tomas A, Rabinovitch Peter S

Abstract excerpt

Mitochondrial defects have been found in aging and several age-related diseases. Mice with a homozygous mutation in the exonuclease encoding domain of mitochondrial DNA polymerase gamma (Polg(m/m)) are prone to age-dependent accumulation of mitochondrial DNA mutations and have shown a broad spectrum of aging-like phenotypes. However, the mechanism of cardiac phenotypes in relation to the role of mitochondrial DNA...

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Identifiers

PMID: 20456298
DOI: 10.1111/j.1474-9726.2010.00581.x
PMCID: PMC3265170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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