Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

31 Oct 2016

Abstract excerpt

mouse model with "humanized" telomere lengths, the devastating dilated cardiomyopathy phenotype seen in patients with DMD was recapitulated. Here, we analyze the degenerative sequelae that culminate in heart failure and death in this mouse model. We report progressive telomere shortening in developing mouse cardiomyocytes after postnatal week 1, a time when the cells are no longer dividing. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitochondrial Function and Pathology
Share to Muscle Physiology and Disorders
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27799523
DOI: 10.1073/pnas.1615340113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathyPMID 27799523Read ↗

Telomeres and Mitochondria in the Aging HeartSemantic proximity Read ↗

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCsSemantic proximity Read ↗

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCsSemantic proximity Read ↗

Inducible Impairment of Polymerase Gamma Activity in Cardiomyocytes Promotes Severe Cardiomyopathy with Cardiac HepatopathySemantic proximity Read ↗

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failureSemantic proximity Read ↗

Mitochondria in Duchenne Muscular Dystrophy-induced Cardiomyopathy: A Prospective Therapeutic Target to Improve Treatment ResponseSemantic proximity Read ↗

Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytesSemantic proximity Read ↗

Mitochondrial defects in cardiomyopathy and neuromuscular disease.Semantic proximity Read ↗

Mitochondrial dysfunction is an early consequence of partial or complete dystrophin loss in mdx mice.Semantic proximity Read ↗

Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulationSemantic proximity Read ↗

A Barth Syndrome Patient-Derived D75H Point Mutation in TAFAZZIN Drives Progressive Cardiomyopathy in Mice.Semantic proximity Read ↗

Cardiac telomere length in heart development, function, and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.