Article
Molecular signature of cardiac remodeling associated with Polymerase Gamma mutation.
Life sciences - 1 Jun 2022
Gorr Matthew W, Francois Ashley, Marcho Lynn M, Saldana Ty, McGrail Erin, Sun Nuo, Stratton Matthew S
Abstract excerpt
AIMS: Metabolic function/dysfunction is central to aging biology. This is well illustrated by the Polymerase Gamma (POLG) mutant mouse where a key residue of the mitochondrial DNA polymerase is mutated (D257A), causing loss of mitochondrial DNA stability and dramatically accelerated aging processes. Given known cardiac phenotypes in the POLG mutant, we sought to characterize the course of cardiac dysfunction in...
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