Article

Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous heart failure

2025-01-20

Abstract excerpt

Metabolic adaptations and flexibility during development and disease play an essential in cardiomyocyte function and survival. We recently reported Glucocorticoid receptor (GR)-Krüppel-like factor 9 (Klf9) axis in mediating metabolic adaptations in cardiomyocytes stimulated with Dexamethasone. Klf9 expression decreases in hypertrophic and failing hearts, suggesting its importance in cardiac homeostasis and its pot...

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Literature Corpus work: e85c5632-8625-5b68-b5ea-05ca0908fcab
DOI: 10.1101/2025.01.16.633464

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