Article

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which is specifically activated by mitochondrial DNA (mtDNA) damage. However, the causal molecular signals responsible for this activation remain elusive. A gene often associ...

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Literature Corpus work: 9f7ca020-110a-5323-8225-ff17eefaf889
DOI: 10.1101/2024.06.02.597064

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