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Article

Cardiomyocyte-intrinsic somatic mtDNA mutations induce an OXPHOS-dependent immune response and promote progressive heart failure.

Science advances - 4 Sept 2026

Bubb Kristina, Rigoni Giovanni, Papadea Polyxeni, Pironti Gianluigi, Misic Jelena, Jiang Shan, Alsina David, Rubalcava-Gracia Diana, Andersson Daniel C, Filograna Roberta, Koolmeister Camilla, Giavalisco Patrick, Wredenberg Anna, Mann Matthias, Rosenberger Florian A, Larsson Nils-Göran

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations accumulate with age, but their mechanistic contribution to aging remains unclear. The classical mtDNA mutator mouse expresses a proofreading-deficient mtDNA polymerase (POLGD257A) and accumulates mtDNA mutations across all tissues leading to premature aging. However, this model cannot resolve whether the aging phenotype results from systemic dysfunction or cell-intrinsic...

Read the complete abstract on PubMed

Topics

Animals
DNA, Mitochondrial
Mutation
Heart Failure
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Myocytes, Cardiac

Oxidative Phosphorylation

Aging

DNA Polymerase gamma

Immunity

Source

Open in PubMed Open full text

Identifiers

PMID: 42696572
DOI: 10.1126/sciadv.aec8606
PMCID: PMC13544208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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