Article

PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain

2026-07-14

Abstract excerpt

<h4>Background</h4> Phospholipase C gamma-2 (PLCγ2) catalyzes the hydrolysis of the membrane phosphatidylinositol-4,5-bisphosphate (PIP 2 ) to form diacylglycerol (DAG) and inositol trisphosphate (IP 3 ), feeding into diverse downstream signaling pathways. PLCG2 polymorphisms have been associated with reduced and/or increased risk of Alzheimer’s disease (AD) and related dementias, longevity, autoinflammation,...

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Literature Corpus work: fbfb69d1-b6b5-51fd-b200-d2787e970507
DOI: 10.64898/2026.07.13.738356

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