Article

Phosphoinositide turnover through PLCγ regulates Draper-dependent engulfment in glia

2026-06-09

Abstract excerpt

Glial engulfment of degenerating neuronal material is essential for nervous system development, maintenance and repair. Genome-wide association studies have identified protective variants in the phosphoinositide-metabolising enzyme PLCG2 that modify Alzheimer’s disease risk, but how PLCG2-dependent phosphoinositide signalling regulates glial engulfment remains unclear. Using Drosophila , we investigated the role...

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Literature Corpus work: 2b9a7a72-f928-5dd4-a99a-633029b3d43d
DOI: 10.64898/2026.06.04.729572

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