Article

Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain

2023-12-08

Abstract excerpt

Phospholipase C gamma-2 (PLCγ2) catalyzes the hydrolysis of the membrane phosphatidylinositol-4,5-bisphosphate (PIP 2 ) to form diacylglycerol (DAG) and inositol trisphosphate (IP 3 ), which subsequently feed into numerous downstream signaling pathways. PLCG2 polymorphisms are associated with both reduced and increased risk of Alzheimer’s disease (AD) and with longevity. In the brain, PLCG2 is highly expressed i...

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Literature Corpus work: cd5aa2d3-7491-50c4-8717-afc5720c37a3
DOI: 10.1101/2023.12.06.570499

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