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The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration

19 Jun 2021

Abstract excerpt

Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif. These receptors recruit kinases such as Syk, BTK, and BLNK to phosphorylate and activate PLCγ2, which then generates 1D-myo-inositol 1,4,5-trisphosphate and diacylglycerol. These...

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PMID: 34157287
DOI: 10.1016/j.jbc.2021.100905

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