Article

Trem2 <sup>R47H</sup> and reduced <i>TREM2</i> expression both mimic human Alzheimer’s disease signatures in mice

2025-12-19

Abstract excerpt

<h4>INTRODUCTION</h4> TREM2 loss of function variants are associated with late-onset Alzheimer’s disease (LOAD). We molecularly assessed mice with the missense variant, R47H (Trem2*R47H HSS ), and mice with additional cryptic splicing and reduced Trem2 expression (Trem2*R47H) while comparing relevance to human LOAD. <h4>METHODS</h4> The aberrant splice acceptor site in the Trem2*R47H mouse was humanized resul...

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Literature Corpus work: f9177bc8-6f93-563d-a2cb-babe4392d29f
DOI: 10.64898/2025.12.17.694758

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