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Weighted burden analysis of exome-sequenced late onset Alzheimer’s cases and controls provides further evidence for a role for <i>PSEN1</i> and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways

2019-04-02

Abstract excerpt

<h4>Summary</h4> Previous studies have implicated common and rare genetic variants as risk factors for late onset Alzheimer’s disease (AD, LOAD). Here, weighted burden analysis was applied to over 10,000 exome sequenced subjects from the Alzheimer’s Disease Sequencing Project. Analyses were carried out to investigate whether rare variants predicted to have a functional effect within a gene were more commonly seen...

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Literature Corpus work
d87805f7-6594-574b-a8d9-546bbd2aeb81
DOI
10.1101/596007
Open publication

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Weighted burden analysis of exome-sequenced late onset Alzheimer’s cases and controls provides further evidence for a role for <i>PSEN1</i> and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathwaysDOI 10.1101/596007
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