Article

An isogenic single-cell atlas of familial Parkinson’s disease mutations reveals convergent changes in dopamine neurons

2026-05-06

Abstract excerpt

<h4>Summary/Abstract</h4> Familial Parkinson’s disease (PD) is caused by mutations in more than twenty genes that affect diverse cellular pathways, including mitochondrial quality control, lysosomal function, and vesicular trafficking. A central question is how mutations impacting these distinct pathways converge to cause the selective degeneration of dopamine neurons. Human pluripotent stem cell (hPSC)-based dis...

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Literature Corpus work: fbd5ca79-0599-5b1d-8b5c-1ca39a338b33
DOI: 10.64898/2026.05.04.722458

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