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Article

iSCORE-PD: an isogenic stem cell collection to research Parkinson's disease.

Nature communications - 17 Jun 2026

Busquets Oriol, Li Hanqin, Syed Khaja Mohieddin, Jerez Pilar Alvarez, Dunnack Jesse, Lo Bu Riana, Verma Yogendra, Pangilinan Gabriella R, Martin Annika, Straub Jannes, Du YuXin, Simon Vivien M, Poser Steven, Bush Zipporiah, Diaz Jessica, Sahagun Atehsa, Gao Jianpu, Hong Samantha, Hernandez Dena G, Levine Kristin S, Pochet Nathalie, Booth Ezgi O, Blanchette Marco, Bateup Helen S, Rio Donald C, Blauwendraat Cornelis, Hockemeyer Dirk, Soldner Frank

Abstract excerpt

Genome-edited human pluripotent stem cells (hPSCs) provide a powerful platform to study complex diseases such as Parkinson's disease (PD). Here, we describe iSCORE-PD, an isogenic collection of 65 genome-edited hPSC lines carrying disease-causing or high-risk variants in 11 PD-linked genes (SNCA, PRKN, PINK1, DJ1/PARK7, LRRK2, ATP13A2, FBXO7, DNAJC6, SYNJ1, VPS13C, and GBA1). All lines are derived from a...

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Source

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Identifiers

PMID: 42310027
DOI: 10.1038/s41467-026-74355-8
PMCID: PMC13434110

Genes

ATP13A2
DNAJC6
FBXO7
GBA1
PARK7
PINK1
PRKN
SNCA
SYNJ1
VPS13C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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