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Article

Single cell transcriptomics of human PINK1 iPSC differentiation dynamics reveal a core network of Parkinson’s disease

2020-09-05

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The heterogenous pathology and complex underlying mechanisms are only partly understood and there is no treatment able to reverse PD progression. Here, we targeted the disease mechanisms by focusing on the ILE368ASN mutation within th...

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Literature Corpus work
19d38c2d-50b8-5f39-8190-52637044b2b0
DOI
10.21203/rs.3.rs-72882/v1
Open publication

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Single cell transcriptomics of human PINK1 iPSC differentiation dynamics reveal a core network of Parkinson’s diseaseDOI 10.21203/rs.3.rs-72882/v1
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