Article

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s disease

2020-09-08

Abstract excerpt

The development of human induced pluripotent stem cells (hiPSC) has greatly aided our ability to model neurodegenerative diseases. However, generation of midbrain dopaminergic (mDA) neurons is a major challenge and protocols are variable. Here, we developed a method to differentiate hiPSCs into enriched populations (>80%) of mDA neurons using only small molecules. We confirmed the identity of the mDA neurons using...

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Literature Corpus work: dac1c28a-95b1-57b4-9573-5bf5c5166841
DOI: 10.1101/2020.09.08.287797

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