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Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson’s Disease Mutations

2024-03-03

Abstract excerpt

Parkinson’s disease (PD) arises from genetic and environmental factors. Human genetics has identified mutations in ∼20 inherited familial genes linked to monogenic forms of PD. To investigate the effects of individual familial PD mutations, human pluripotent embryonic stem cells (hPSCs) carrying 12 distinct familial PD mutations were differentiated into midbrain lineage cells, including dopaminergic (mDA) neurons....

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Literature Corpus work
e935bd60-bed9-56c1-9016-c53f3e158e13
DOI
10.1101/2024.02.28.582420
Open publication

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Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson’s Disease MutationsDOI 10.1101/2024.02.28.582420
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