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Article

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.

Cell reports - 14 Jun 2016

Lin Lin, Göke Jonathan, Cukuroglu Engin, Dranias Mark R, VanDongen Antonius M J, Stanton Lawrence W

Abstract excerpt

The fact that Parkinson's disease (PD) can arise from numerous genetic mutations suggests a unifying molecular pathology underlying the various genetic backgrounds. To address this hypothesis, we took an integrated approach utilizing in vitro disease modeling and comprehensive transcriptome profiling to advance our understanding of PD progression and the concordant downstream signaling pathways across divergent...

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Identifiers

PMID: 27264186
DOI: 10.1016/j.celrep.2016.05.022

Genes

RBFOX1

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