Article

Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell loss

2024-10-11

Abstract excerpt

<h4>Background</h4> Mutations causing Parkinson’s disease (PD) give diverse pathological phenotypes whose cellular correlates remain to be determined. For example, those with PRKN loss of function mutations have significantly earlier selective vulnerability of dopamine neurons, those with SNCA mutations have increased alpha-synuclein deposition, while those with LRRK2 mutations have additional deposition of ta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 262c8d47-8e23-557f-99c4-2bb6b9799e10
DOI: 10.1101/2024.10.07.617117

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell lossDOI 10.1101/2024.10.07.617117Read

Dopamine and cortical neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunctionSemantic proximity Read

An isogenic single-cell atlas of familial Parkinson’s disease mutations reveals convergent changes in dopamine neuronsSemantic proximity Read

Disease‐specific phenotypes in dopamine neurons from human iPS‐based models of genetic and sporadic Parkinson's diseaseSemantic proximity Read

Diverging Parkinson’s Disease Pathology between patient-derived GBA N370S , LRRK2 G2019S and engineered SNCA A53T iPSC-derived Dopaminergic NeuronsSemantic proximity Read

Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a SNCA TriplicationSemantic proximity Read

Highly enriched hiPSC-derived midbrain dopaminergic neurons robustly models Parkinson’s diseaseSemantic proximity Read

Mitochondrial Dysfunction in Dopaminergic Neurons Derived from Patients with LRRK2- and SNCA-Associated Genetic Forms of Parkinson’s DiseaseSemantic proximity Read

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology.Semantic proximity Read

Recapitulating Parkinson’s pathology in human iPSC dopaminergic neurons reveals new mechanistic insights into Lewy body formation and heterogeneitySemantic proximity Read

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neuronsSemantic proximity Read

A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical and dopaminergic-like induced neuronsSemantic proximity Read

Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia PathologiesSemantic proximity Read