Article

Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide Hydrolase

2025-12-19

Abstract excerpt

<title>Abstract</title> <p> Human soluble epoxide hydrolase (sEH) is an important modulator of cardiovascular, brain and renal health, and a promising therapeutical target for several pathologies. Its C-terminal domain (CTD) possesses hydrolytic activity which is responsible for decreasing the level of beneficial bioactive epoxy fatty acids. In this work we uncover the mechanisms of allosteric inhibition exerted...

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Literature Corpus work: fbc2a3b0-23d5-5837-bc2a-3caae36e2a5d
DOI: 10.21203/rs.3.rs-8030999/v1

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