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Article

The endocannabinoid hydrolase FAAH is an allosteric enzyme.

Scientific reports - 10 Feb 2020

Dainese Enrico, Oddi Sergio, Simonetti Monica, Sabatucci Annalaura, Angelucci Clotilde B, Ballone Alice, Dufrusine Beatrice, Fezza Filomena, De Fabritiis Gianni, Maccarrone Mauro

Abstract excerpt

Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids. Parallel orientation of FAAH monomers likely allows both subunits to simultaneously recruit and cleave substrates. Here, we show full inhibition of human and rat FAAH by means of enzyme...

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Identifiers

PMID: 32041998
DOI: 10.1038/s41598-020-59120-1
PMCID: PMC7010751

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