Article

STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE

2024-09-05

Abstract excerpt

Soluble epoxide hydrolase (sEH) represents a promising target for inflammation-related diseases as it hydrolyzes highly anti-inflammatory epoxy-fatty acids (EpFAs) to the less active corresponding diols. 1 sEH harbours two distinct catalytic domains, the C-terminal hydrolase domain and the N-terminal phosphatase domain which are connected by a proline-rich linker. 2 Although potent inhibitors of enzymatic activi...

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Literature Corpus work: 47b9ee8e-d66b-596a-ac86-9e8676bca5cb
DOI: 10.1101/2024.09.05.611393

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